The aim is to develop a new detection and imaging systems, which will be applied in electron microscopy, medical diagnostics, measuring techniques and other applications for detection of ionizing particles. The development consists of (i) design of new generation of detection units for electron microscopy, (ii) developement of extremely thin UV emitting scintillation screens and (iii) construction of noiseless imaging systems for ionizing radiation based on the Medipix chip or equivalent.